Leeds boss Kevin Blackwell will make enforced changes due to illness and injury.
He could be without as many as six of the side that started in the goalless draw with Plymouth last week.
Blackwell: 'I've got a couple who will not play. I'm not prepared to say who they are, but there will be some enforced changes.'
Skipper Paul Butler, Stephen Crainey, Gary Kelly and on-loan Danny Graham have all been struggling with a virus.
Blackwell also has concerns over defender Sean Gregan, who injured his ribs against Plymouth, Frazer Richardson, who has suffered a recurrence of his knee problem and Shaun Derry (ankle).
Steve Stone (Achilles) edged closer to his first-team debut with a half-hour run-out with the reserves this week and Richard Cresswell (knee) is also making steady progress.
READING v LEEDS LEAGUE HISTORY
2005/2006 Sat 29 Oct Reading 1 - 1 Leeds Utd. Championship
2004/2005 Sat 12 Feb Leeds Utd. 3 - 1 Reading Championship
Tue 19 Oct Reading 1 - 1 Leeds Utd. Championship
1997/1998 Tue 18 Nov Leeds Utd. 2 - 3 Reading League Cup
1995/1996 Wed 10 Jan Leeds Utd. 2 - 1 Reading League Cup
1987/1988 Sat 12 Dec Reading 0 - 1 Leeds Utd. Second Division
Sat 22 Aug Leeds Utd. 0 - 0 Reading Second Division
1986/1987 Wed 22 Apr Reading 2 - 1 Leeds Utd. Second Division
Sat 13 Sep Leeds Utd. 3 - 2 Reading Second Division
1927/1928 Sat 24 Mar Reading 0 - 1 Leeds Utd. Second Division
Sat 12 Nov Leeds Utd. 6 - 2 Reading Second Division